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Home - Products - Metabolic Enzyme/Protease - Adenylate Cyclase - NB 001

NB 001

CAS No. 686301-48-4

NB 001 ( NB001;NB-001 )

Catalog No. M15621 CAS No. 686301-48-4

A potent, relatively selective and orally active adenylyl cyclase 1 (AC1) inhibitor with IC50 of 10 uM (cAMP production inhibition).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    NB 001
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, relatively selective and orally active adenylyl cyclase 1 (AC1) inhibitor with IC50 of 10 uM (cAMP production inhibition).
  • Description
    A potent, relatively selective and orally active adenylyl cyclase 1 (AC1) inhibitor with IC50 of 10 uM (cAMP production inhibition); displays >10-fold selectivity over AC5/6/7/8; shows analgesic effect in animal models of neuropathic pain, without no significant effect on behavioral anxiety.
  • Synonyms
    NB001;NB-001
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Adenylate Cyclase
  • Recptor
    Adenylate Cyclase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    686301-48-4
  • Formula Weight
    264.33
  • Molecular Formula
    C12H20N6O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    OCCCCCNCCN1C=NC2=C(N)N=CN=C12
  • Chemical Name
    5-[[2-(6-amino-9H-purin-9-yl)ethyl]amino]-1-pentanol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wang H, et al. Sci Transl Med. 2011 Jan 12;3(65):65ra3.
2. Brand CS, et al. J Pharmacol Exp Ther. 2013 Nov;347(2):265-75.
3. Zhang MM, et al. Mol Brain. 2014 Jun 16;7:47.
4. Sethna F, et al. Nat Commun. 2017 Feb 20;8:14359.
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