NB 001

CAS No. 686301-48-4

NB 001 ( NB001;NB-001 )

Catalog No. M15621 CAS No. 686301-48-4

A potent, relatively selective and orally active adenylyl cyclase 1 (AC1) inhibitor with IC50 of 10 uM (cAMP production inhibition).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 200 Get Quote
10MG 295 Get Quote
25MG 498 Get Quote
50MG 710 Get Quote
100MG 963 Get Quote
500MG 1935 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    NB 001
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, relatively selective and orally active adenylyl cyclase 1 (AC1) inhibitor with IC50 of 10 uM (cAMP production inhibition).
  • Description
    A potent, relatively selective and orally active adenylyl cyclase 1 (AC1) inhibitor with IC50 of 10 uM (cAMP production inhibition); displays >10-fold selectivity over AC5/6/7/8; shows analgesic effect in animal models of neuropathic pain, without no significant effect on behavioral anxiety.
  • Synonyms
    NB001;NB-001
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Adenylate Cyclase
  • Recptor
    Adenylate Cyclase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    686301-48-4
  • Formula Weight
    264.33
  • Molecular Formula
    C12H20N6O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    OCCCCCNCCN1C=NC2=C(N)N=CN=C12
  • Chemical Name
    5-[[2-(6-amino-9H-purin-9-yl)ethyl]amino]-1-pentanol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wang H, et al. Sci Transl Med. 2011 Jan 12;3(65):65ra3.
2. Brand CS, et al. J Pharmacol Exp Ther. 2013 Nov;347(2):265-75.
3. Zhang MM, et al. Mol Brain. 2014 Jun 16;7:47.
4. Sethna F, et al. Nat Commun. 2017 Feb 20;8:14359.
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